منابع مشابه
Humpty Dumpty: Putting iBGP Back Together Again
Humpty Dumpty is the anthropomorphic nursery-rhyme egg broken into many pieces. Similarly, we have many pieces of measurement data to represent the current iBGP state. However, unlike the nurseryrhyme where the King’s men couldn’t put Humpty together again, we present a systematic approach to putting all the pieces of measured iBGP data together to obtain a more complete picture of a network’s ...
متن کاملHope for Humpty Dumpty: systems biology of cellular signaling.
One definition of systems biology is the modeling of the relationships, or networks, within and/or between large-scale data sets. As scientists’ knowledge of living systems has grown, it has become increasing difficult to understand relationships between all the components of a biological network by intuitive approaches alone. The value of systems biology is that it (1) helps us to organize inf...
متن کاملhumpty dumpty Is Required for Developmental DNA Amplification and Cell Proliferation in Drosophila
The full complement of proteins required for the proper regulation of genome duplication are yet to be described. We employ a genetic DNA-replication model system based on developmental amplification of Drosophila eggshell (chorion) genes [1]. Hypomorphic mutations in essential DNA replication genes result in a distinct thin-eggshell phenotype owing to reduced amplification [2]. Here, we molecu...
متن کاملShattering the consensus on end-of-life care: was the Schiavo case palliative medicine's Humpty Dumpty?
In October of 2005, a two-day conference, “Controversies in End-of-Life Care: Terri Schiavo’s Lessons,” was jointly sponsored by Baystate Medical Center and the Smith College School for Social Work. Both the conference and this special issue of the journal are prompted by recognition that the Schiavo case has clearly generated considerable national attention, and it consequently offers palliati...
متن کاملPutting Humpty-Dumpty Together: Clustering the Functional Dynamics of Single Biomolecular Machines Such as the Spliceosome.
The spliceosome is a biomolecular machine that, in all eukaryotes, accomplishes site-specific splicing of introns from precursor messenger RNAs (pre-mRNAs) with high fidelity. Operating at the nanometer scale, where inertia and friction have lost the dominant role they play in the macroscopic realm, the spliceosome is highly dynamic and assembles its active site around each pre-mRNA anew. To un...
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ژورنال
عنوان ژورنال: Indian Journal of Endocrinology and Metabolism
سال: 2020
ISSN: 2230-8210
DOI: 10.4103/ijem.ijem_546_20